SCPacker service enables users to retrieve a three-dimensional protein structure and model an amino acid substitution within the selected atomic coordinates. To begin, identify the protein of interest. The system accepts queries using a UniProt accession (e.g., P05067) or a PDB identifier (e.g., 1EDI). If the UniProt accession is unknown, it is recommended to query the UniProt knowledgebase (https://uniprot.org) first to obtain the canonical identifier. Upon a successful query, the system will display available structural models in a tabular format, with each row representing a single polypeptide chain. Select the desired model and click the associated visualization in the rightmost column to proceed to the residue substitution step.

Important:  Processing of large structures that are not distributed in the standard PDB file format may currently fail. This limitation is under active development.

Cite us: Petrovskiy DV, Nikolsky KS, Rudnev VR, Kulikova LI, Butkova TV, Malsagova KA, Kopylov AT, Kaysheva AL. Modeling Side Chains in the Three-Dimensional Structure of Proteins for Post-Translational Modifications. Int J Mol Sci. 2023 Aug 30;24(17):13431. doi: 10.3390/ijms241713431. PMID: 37686234.